About SSRIs (Selective Serotonin Reuptake Inhibitors)

SSRIs, or selective serotonin reuptake inhibitors, are a class of prescription drugs most commonly prescribed for depression, though they may be used to treat anxiety disorders, post-traumatic stress disorder and obsessive-compulsive disorder. Some SSRIs may also be prescribed for bulimia and panic disorders. The most common brand name SSRIs are Lexapro (escitalopram), Zoloft (sertraline hydrochloride), Paxil (paroxetine), Luvox (fluvoxamine), Prozac (fluoxetine) and Celexa (citalopram).

How does an SSRI work?

Serotonin is a neurotransmitter (a chemical substance that transmits nerve impulses) that is thought to affect mood regulation, sleep, learning and blood vessel constriction. Low levels of serotonin have been associated with depression. An SSRI is intended to work by blocking or delaying serotonin from being reabsorbed by the nerve cell that released it. This enables serotonin to remain active and allows it to be absorbed by other nerves, thus improving a patient's mood.

SSRIs: Side Effects and Withdrawal Symptoms

Since their introduction on the worldwide market, SSRIs have been met with much controversy. An article based on a meta-analysis, published in January of 2010 titled "Antidepressant Drug Effects and Depression Severity" in the Journal of the American Medical Association stated that "The magnitude of benefit of antidepressant medication compared with placebo ... may be minimal or nonexistent, on average, in patients with mild or moderate symptoms." There have also been numerous reports of adverse side effects, ranging from nausea and headaches all the way to suicide. Birth defects, including persistent pulmonary hypertension of the newborn, have also been linked to SSRIs.

When taken by children and adolescents, SSRIs are recognized as increasing the likelihood of self-harm and suicidal thoughts. An analysis of clinical trials conducted by the FDA (Food and Drug Administration) in 2004 found that there were significant increases of these risks in children and adolescents, by about 80%. The analysis also found that there was an increased risk of agitation and hostility of approximately 130%.

SSRI antidepressants have also been recognized as creating dependency in some patients. Though SSRIs are not likely to be abused, abruptly discontinuing use may produce serious withdrawal symptoms.

SSRI Lawsuits

If you or someone you love suffered a serious side effect from taking or discontinuing an SSRI, you may have the right to take legal action against the drug's manufacturer. A pharmaceutical injury attorney at Arnold & Itkin LLP can review your case to determine how to move forward. Your initial consultation is free, and we handle drug injury claims on a contingent fee basis, meaning you pay no legal fees unless we negotiate a settlement or win a jury verdict on your behalf.

For more information about SSRIs, contact a medical injury lawyer at our firm.